Title : Roles and mechanism of human amniotic mesenchymal stem cells in the treatment of liver fibrosis
Abstract:
Stem cell therapy has been considered as practical and attractive approach for treatment of many diseases clinically in recent years. Human amniotic mesenchymal stem cells (hAMSCs) are derived from the amnion tissues of the placenta which is normally discarded upon delivery, and they are a relatively easy accessible type of stem cells without ethical concerns. In addition, the hAMSCs were characterized with non-tumorigenicity, low immunogenicity, high histocompatibility and strong proliferation. Studies have shown that mesenchymal stem cells (MSCs) from a variety of tissues can improve liver fibrosis. Recently, we observed that hAMSCs significantly protected mice from liver fibrosis in vitro and the underlying molecular mechanism has been elucidated in vivo and in vitro. Obviously, our study will provide an insight in the treatment of liver fibrosis clinically.
