Title : Stem cells inhibit ferroptosis after spinal cord injury
Abstract:
Spinal cord injury (SCI) has different aetiologies, complex pathogenesis, and diverse pathological changes. With current treatment effects are not precise, and the prognosis is poor. After SCI, neurons die in various forms. Among them, ferroptosis, is one of important factors causing dysfunction after SCI, and none of the existing traditional treatments have been proven to block its occurrence. Meanwhile, stem cells, specifically mesenchymal stem cells (MSCs), are considered to can direct differentiation into neurons, while also play a role in inhibiting neuroinflammation, inhibiting scarring, stimulating angiogenesis and providing nutritional support. And they are promised for reversing spinal cord neuronal ferroptosis after SCI. However, there is no precise and reliable report on this aspect. Unfortunately, only a few studies on the treatment of neurological diseases that can provide a partial basis for the treatment of ferroptosis by MSCs, almost no studies directly on ferroptosis after SCI. In addition, MSCs could also inhibit various forms of cell death after SCI, including apoptosis, pyroptosis and autophagy. They are supported by corresponding studies. In summary, ferroptosis is an important programmed cell death after SCI, and inhibition of it has been shown to be beneficial to reverse neurological dysfunction after SCI. Meanwhile, stem cells are promising treatments for SCI, which have proven to help reverse adverse outcomes in SCI, and has been shown to have the potential to inhibit ferroptosis after SCI. Overall, this presentation provides a basis, reference and inspiration for future research on stem cells in the treatment of ferroptosis after SCI, inspire further research, ultimately benefit clinical.
