2nd Edition of International Conference on Cell & Stem Cell Research

August 21-23, 2023 | London, UK

August 21 -23, 2023 | London, UK
Stem Cells - 2023

Sahar Mohamed Mahdy Omar

Speaker at Cell & Stem Cell Research 2023 - Sahar Mohamed Mahdy Omar
Ain Shams University, Egypt
Title : Comparative study on the effect of adipose-derived stem cells versus alpha-lipoic acid inautologus fat graft survival


Autologous fat transfer is a popular option for soft tissue augmentation but has a low survival rate. So, enriching the transplanted fat with stem cells (cell assisted lipotransfer) or oral administration of alpha-lipoic acid (ALA) before and after graft injection, were thought to increase the survival rate of the transplanted fat.

Aim of Study: Is to compare between cell-assisted lipotransfer (CAL) and ALA therapy in improvement of fat graft survival.

Materials and Methods: Thirty adult female albino rats were used and divided into three groups.

Group I: the control group. Group II: CAL group received autologous fat mixed with adipose derived stem cells (ASCs). Group III: ALA group in which animals received oral ALA four days before fat transplantation and continued throughout experiment. Fat grafts were collected from the sites of injection after twenty-eight days. Histological and immune histochemical studies were performed. Statistical analysis was also done.

Results: Histological evaluation revealed atrophy and death of adipocytes with formation of fat cysts. Severe inflammatory infiltration with giant cells formation and fibrosis were detected Significant decrease of VEGF reaction was seen. In CAL group significant increase in number of intact adipocytes together with decrease in inflammation and fibrosis occurred. Moreover, significant increase in VEGF reaction was observed. In ALA group, significant decrease in number of intact adipocytes and VEGF reaction was detected compared with CAL group. Also, significant increase in inflammatory infiltration and fibrosis were detected compared to CAL group.

Conclusion: Both ASCs and ALA showed improvement in all histological parameters compared with control group. However, enrichment of fat with ASCs showed the best results.


Dr. Sahar M.M. Omar now is a professor doctor at Ain Shams University and Galala university and has been former Head of Histology Department at Armed Forces College of Medicine.  has completed her Ph.D. in Histology & cell biology at Ain Shams University from 2000 to 2005. Dr. Sahar is a FAIMER faculty (foundation for advancement of international medical education and research). She is also a Certified International Professional Trainer CIPT MISSOURI State University. Dr. Sahar has recently written book chapter entitled “ Mesenchymal Stem Cells For Treating Ocular Surface Diseases: A Review” in the book named “ Issues and Developments In medicine and Medical research”. She contributed as a speaker at  global webinar on stem cell during November 11-12-2021, she also attended the BIT's 10th World Congress of Regenerative Medicine & Stem Cells -2016 in China and gave a talk titled as "Bone Marrow Mesenchymal Stem Cell Transplantation in a Rabbit Corneal Alkali Burn Model.". she has published more than 15 papers in stem cells and tissue engineering and cellular therapy in reputed journals and has been serving as an editorial board member of repute in Journal of Stem Cells and Genetics, Journal of Embryology & Stem Cell Research, Journal of dental and medical science & Journal of Genetics, Cellular and Molecular Biology. Associate editor in Journal of Stem Cell Research and therapeutics. Also serving as Board reviewer in Journal of Stem Cell Research and Medicine & Journal of nanomedicine and nanoscience research.