Cell Aging and Senescence

Cellular ageing is described as a gradual loss of cellular functioning and eventual cell death caused by a continuous decrease in resistance to stress and other cellular damages. Because of the presence of ageing pigments known as lipofuscin granules, ageing cells are another primary source of autofluorescence. Cellular ageing is particularly intriguing since it proposes a mechanism for organismal ageing, implying that reversing ageing at the cellular level could enhance lifespan. Cellular senescence is a durable cell cycle halt in which proliferating cells become resistant to growth-promoting stimuli, most commonly as a result of DNA damage. The biological role of senescence is complex, as senescent cells have both protective and detrimental effects, which are mostly dependent on physiological circumstances. It's inappropriate to use the phrases ageing and cellular senescence interchangeably.

• Diet and Ageing
• Chromosome and Telomere Regulation
• Nuclear Trafficking and Organization
• Transcriptional Regulation
• Replicative Ageing
• Chronological Ageing
• DNA Damage-Induced Senescence
• Biomarkers of Senescence