Stem Cell Niche

A stem-cell niche is a region of a tissue that provides a specialised milieu for stem cells to exist in an undifferentiated, self-renewing form. The stem-cell niche cells interact with stem cells to keep them alive or induce differentiation. The microenvironment and the stem cell are the two main components of a stem cell niche, and each of their functions is dependent on the other. Stem cell niches have been postulated to play a key role in the preservation of stem cells in the male germline, haematological system, epidermis, intestinal epithelium, and adult brain system. The ability to recognise stem cells in vivo in their natural environment is required for characterization of these stem cell niches. In tissue homeostasis, regeneration, and disease, the stem cell niche is critical.

• Adult Stem Cells and Their Niches
• Interactions Between Stem Cells and Their Environment
• Designing Stem Cell Niches
• Properties of the Stem Cell Niche