The cytoskeleton is a three-dimensional network of filamentous proteins that connects all of the cell's regions and components. Many elements of cell physiology, including mitosis, cell division, volume regulation, cell stiffness, cell polarity, and extracellular matrix patterning, are governed by the cytoskeleton. These events have an impact on tissue differentiation and development. A cytoskeleton exists in some form in all cells, including bacteria. This network serves multiple purposes, including providing structural support for the cell, a framework for active transport mechanisms, and a system for mechanical force generation and transmission. Both intracellular and external signalling signals are received, integrated, and transmitted by the cytoskeleton. Before reaching the cytoskeleton, most of these stimuli must pass via a lipid bilayer.