Pluripotency and its Mechanism

Individual cells' ability to initiate all lineages of the mature organism in response to cues from the embryo or cell culture environment is known as pluripotency. A pluripotent cell is a blank slate with no preconceived program. Pluripotent stem cells have the ability to self-renew as well as generate all of the cell types that make up the three germ layers. Pluripotent stem cells were previously produced from cultures acquired from the blastocyst's interior cell mass (embryonic stem cells — ESCs). In the last few years, we've learned a lot more about the molecular mechanisms underlying pluripotency. Both transcriptional and epigenetic regulation are two fundamental mechanisms enabling pluripotency, it has become increasingly obvious.

• Molecular Mechanisms Underlying Pluripotency Induction
• Reprogramming Somatic Cells to A Pluripotent State
• Potential of Using iPSCs in Clinical Practice
• Clinical Use of Pluripotent Cells